What causes IgA Nephropathy? What are the signs and symptoms of IgA nephropathy? The most common signs are Hematuria : Having blood in your urine that can sometimes make it dark brown or cola colored. Proteinuria : Foamy urine due to large amounts of protein leaking into your urine. What tests are done to find out if I have IgA nephropathy? These tests are: Urine test: A urine test will help find protein and blood in your urine.
Blood test: A blood test will help find levels of protein, cholesterol, and wastes in your blood. Glomerular filtration rate GFR : A blood test will be done to know how well your kidneys are filtering the wastes from your body. Kidney biopsy: In this test, a tiny piece of your kidney is removed with a special needle, and looked at under a microscope. The kidney biopsy may show if you have a certain type of a protein that helps your body fight infection, called an IgA antibody, in the glomerulus.
How is IgA Nephropathy treated? Will I have kidney failure because of IgAN? If you have a family history of the disease, talk with your doctor about what you can do to keep your kidneys healthy, such as reducing high blood pressure and keeping your cholesterol at healthy levels.
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This content does not have an English version. This content does not have an Arabic version. Request an Appointment at Mayo Clinic. Kidney cross section Open pop-up dialog box Close. Kidney cross section Blood enters your kidneys through your renal arteries. Share on: Facebook Twitter. Show references IgA nephropathy. National Kidney Foundation.
Accessed March 27, Gilbert SJ, et al, eds. Immunoglobulin A nephropathy and related disorders. Experts suspect that some people may have a genetic predisposition to the disease.
It's also possible that the disease is caused by an autoimmune response in which the body's immune system mistakenly attacks healthy tissue.
Cigarette smoking greatly increases your risk of Buerger's disease. But Buerger's disease can occur in people who use any form of tobacco, including cigars and chewing tobacco.
People who smoke hand-rolled cigarettes using raw tobacco and those who smoke more than a pack and half of cigarettes a day may have the greatest risk of Buerger's disease. The rates of Buerger's disease are highest in areas of the Mediterranean, Middle East and Asia where heavy smoking is most common. Long-term infection of the gums has been linked to the development of Buerger's disease, though the reason for this connection isn't yet clear.
Buerger's disease is far more common in males than in females. However, this difference may be linked to higher rates of smoking in men.
If Buerger's disease worsens, blood flow to your arms and legs decreases. This is due to blockages that make it hard for blood to reach the tips of your fingers and toes. Tissues that don't receive blood don't get the oxygen and nutrients they need to survive. This can cause the skin and tissue on the ends of your fingers and toes to die gangrene. Signs and symptoms of gangrene include black or blue skin, a loss of feeling in the affected finger or toe, and a foul smell from the affected area.
People with IgA nephropathy have a defective version of immunoglobulin A. The defective IgA forms chains that get stuck in the kidneys. IgA nephropathy affects millions of people worldwide. Treatment typically involves controlling your blood pressure and cholesterol levels with medications.
Some people with IgA nephropathy will eventually need a kidney transplant. In the early stages of IgA nephropathy, the main symptom is blood in the urine. In medical terms, this is called hematuria. Symptoms usually start between the ages of 15 and 35, but they may go unnoticed for years because the amount of blood in the urine is very small.
If the disease progresses and starts to impair the function of your kidneys, you may also experience:. An immunoglobulin or antibody is a large protein that the immune system uses to kill harmful bacteria and viruses. One type of immunoglobulin is immunoglobulin A or IgA. Instead of binding only to bacteria and viruses, the IgA mistakenly attaches to other IgA molecules and creates long chains.
These IgA deposits result in an inflammatory reaction in the body. This inflammation can eventually cause kidney damage. Researchers believe there is a genetic component to the disease because it sometimes runs in families. Men are two to three times more likely to have it than women. The condition is also more common in Native Americans, Caucasians, and Asians. IgA nephropathy may first be noticed when a routine test reveals protein and red blood cells in your urine.
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